Developmental Expression of P-glycoprotein in the Rat Brain

Functional expression of P-glycoprotein in rat brain microglia.

In the central nervous system, the primary targets of the human immunodeficiency virus-1 (HIV-1) are microglia, resulting in a disorder called HIV-1 dementia. P-glycoprotein (P-gp), a membrane-associated ATP-dependent efflux transporter, limits entry into the brain of numerous xenobiotics, including anti-HIV drugs (i.e., protease inhibitors). This project investigates the functional expression ...

evaluation of the functional role of p-glycoprotein in brain uptake of tramadol in rat

the effect of e-64 on the developmental competence of sheep cocs during in vitro maturation

in the present study, the effect of e-64 at different concentrations (0.5, 1, 5 and 10 µm) added to (1) the ivm medium on oocyte nuclear maturation and developmental competence of ovine oocytes, and (2) to the ivc medium on embryonic development of ovine embryos were investigated.

P-glycoprotein expression during tumor progression in the rat liver.

P-Glycoprotein (Pgp) has been shown to mediate multidrug resistance in tumor cell lines. Overexpression of Pgp has been detected in clinical cancer samples of many histological types. The basis and biological significance of such increases in Pgp expression are not well understood. In this study, the expression of Pgp during stepwise progression to rat liver cancer was examined to investigate t...

P-Glycoprotein Expression during Tumor Progression in the Rat Liver1

P-Glycoprotein (Pgp) has been shown to mediate multidrug resis tance in tumor cell lines. Overexpression of Pgp has been detected in clinical cancer samples of many histolÃ3gica!types. The basis and bio logical significance of such increases in Pgp expression are not well understood. In this study, the expression of Pgp during stepwise pro gression to rat liver cancer was examined to investigat...